2017-08-22

Patent: cannabinoid as antioxidants and neuroprotectants

United States Patent Patent N0.: US 6,630,507 B1 Date of Patent: Oct. 7, 2003 ABSTRACT Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes Cannabinoids useful in the treatment and prophylaxis of Wide variety of oxidation associated diseases, such as ischemic, age-related, infammatory and autoimmune diseases. […]

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2017-08-22

Antidepressant-like effects of cannabidiol in mice

Background and purpose: Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces anxiolytic- and antipsychotic-like effects in animal models. Effects of CBD may be mediated by the activation of 5-HT1A receptors. As 5-HT1A receptor activation may induce antidepressant-like effects, the aim of this work was to test the hypothesis that CBD would have […]

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2017-08-22

Cannabinoids for ablating neuroinflammatory disease

Abstract Cannabinoids have been reported to alter the activities of immune cells in vitro and in vivo. These compounds may serve as ideal agents for adjunct treatment of pathological processes that have a neuroinflammatory component. As highly lipophilic molecules, they readily access the brain. Furthermore, they have relatively low toxicity and can be engineered to […]

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2017-08-22

CBD: for lessening the impact of inflammation on oxidative stress

Abstract Oxidative stress with reactive oxygen species generation is a key weapon in the arsenal of the immune system for fighting invading pathogens and to initiate tissue repair. If excessive or unresolved, however, immune-related oxidative stress can initiate further increasing levels of oxidative stress that cause organ damage and dysfunction. Targeting oxidative stress in these […]

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2017-08-22

Cannabinoids as novel anti-inflammatory drugs

Abstract Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive principle in marijuana, as well as the identification of cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid […]

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2017-08-22

Effects of cannabidiol in the treatment of Parkinson’s disease

Abstract Introduction: Parkinson’s disease (PD) has a progressive course and is characterized by the degeneration of dopaminergic neurons. Although no neuroprotective treatments for PD have been found to date, the endocannabinoid system has emerged as a promising target. Methods: From a sample of 119 patients consecutively evaluated in a specialized movement disorders outpatient clinic, we […]

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2017-08-22

Case report: Parkinson’s disease

SUMMARY What is known and objective: Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. We have described the effects of CBD in RBD symptoms in […]

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2017-08-22

Alzheimer’s disease: taking the edge off with cannabinoids

Alzheimer’s disease is an age-related neurodegenerative condition associated with cognitive decline. The pathological hallmarks of the disease are the deposition of b-amyloid protein and hyperphosphorylation of tau, which evoke neuronal cell death and impair inter-neuronal communication. The disease is also associated with neuroinflammation, excitotoxicity and oxidative stress. In recent years the proclivity of cannabinoids to […]

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2017-08-22

Cannabidiol and other cannabinoids reduce microglial activation

Abstract Microglial activation is an invariant feature of Alzheimer’s disease (AD). It is noteworthy that cannabinoids are neuroprotective by preventing β-amyloid (Aβ)-induced microglial activation both in vitro and in vivo. On the other hand, the phytocannabinoid cannabidiol (CBD) has shown anti-inflammatory properties in different paradigms. In the present study, we compared the effects of CBD […]

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