Patent: cannabinoid as antioxidants and neuroprotectants

United States Patent

Patent N0.: US 6,630,507 B1

Date of Patent: Oct. 7, 2003


Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes Cannabinoids useful in the treatment and prophylaxis of Wide variety of oxidation associated diseases, such as ischemic, age-related, infammatory and autoimmune diseases. The Cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurode generative diseases, such as Alzheimer’s disease, Parkinson’s disease and HIV dementia. Nonpsychoactive Cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive Cannabinoids at high doses useful inthe method of the present invention. A particular disclosed class of Cannabinoids useful as neuroprotective antioxidants is formula (I) Wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.